Posted by
Pat on Saturday, August 15, 2009 8:17:52 PM
The National Health Service in Britain has been using
comparative effectiveness analysis for quite some time. NICE stands for the National Institute for
Health and Clinical Excellence. This
organization has defined an upper limit on treatment costs, and if the cost
exceeds this pre-set limit, then the treatment is denied. It
does not matter if the drug is effective or
not. That means that there are many beneficial drugs that are simply
not
available to patients.As this panel can decide who gets treatment and
who does not, and if the proposed treatment is life-saving or
life-prolonging, it can most certainly be called a "death panel".
How does this work? A comparative effective analysis starts
with the perceived patient’s utility given the disease burden. The QALY, or
quality of life-adjusted years is an estimate of the number of years of life
gained given the proposed intervention. Each year of perfect health is assigned
a value of 1.0. A patient in a wheelchair is given a correspondingly lower
value as is a patient who is elderly; this value is not clearly defined and is
rarely based upon patient input.
Consider an example. Suppose a cancer drug for patients with
liver cancer allows a patient to live an average of 18 months compared to not
using the drug. However, as with most
cancer drugs, there are potent side effects. Suppose that the analyst decides
that the quality of life is only 40% of perfect health (giving a weight of
0.4). Then the drug gives 1.5*0.4=0.6 QALYs to the patient. Suppose that at the
initial introduction of this drug that it costs $1000/month, or about $18,000
for the anticipated additional life of the patient. Then the cost per QALY is
equal to 18,000/0.6=$30,000 per year of life saved. According to the NICE
organization, this drug then is too costly regardless of the fact that there is
no comparable drug that is effective in prolonging the patient’s life. However,
suppose the analyst uses a measure of 60% of perfect health. Then the drug
gives 1.5*0.6=0.9 QALYs to the patient at a cost of $20,000, which brings the
amount closer to the pre-set value defined by NICE. Therefore, this definition
of a scale of perfect health is of enormous importance. In fact, NICE has
denied such a cancer drug because of its cost.
If a person is otherwise young and healthy and a drug costs
$10,000 per year, then the
QALY is $10,000. However, if a patient is older and has a chronic condition,
then that patient’s utility may be defined as exactly half that of a young and
healthy person. In that case, the QALY is $20,000 for the same drug. If the
patient is old and has two or more chronic conditions, then the patient’s
utility could be defined as 25% that of a young and healthy person. In that
case, the QALY IS $40,000 per year of life saved. By defining $15,000 as the upper limit for treatment,
it is easy to see how the definition of a person’s utility can be used to deny
care to the elderly.